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Bone construction and resorption are complex processes and the increase in bone density that the bisphosphonates are able to effect leads to a complicated cascade of hormonal and muscuoskeletal effects.

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Bisphosphonates are a class of drugs that are favorably used in the prevention and treatment of glucocorticoid-induced bone loss.

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All participants were provided calcium and vitamin D supplements at baseline and 6 months, so that their total daily intake from diet plus supplements approximated 1200 mg and 1000 IU, respectively.

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Among the women who had new vertebral fractures, the proportion with two or more fractures was much lower in the combined alendronate groups (18 percent) than in the placebo group (68 percent).

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