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Bone construction and resorption are complex processes and the increase in bone density that the bisphosphonates are able to effect leads to a complicated cascade of hormonal and muscuoskeletal effects.

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Bisphosphonates are a class of drugs that are favorably used in the prevention and treatment of glucocorticoid-induced bone loss.

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Among the women who had new vertebral fractures, the proportion with two or more fractures was much lower in the combined alendronate groups (18 percent) than in the placebo group (68 percent).

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